골육종으로 진행된 개화성 골 이형성증의 증례보고
Osteogenic sarcoma is primary malignant bone tumor. It can arise de novo or from the benign precursors lesions, likePaget’s disease, giant cell tumor, chronic osteomyelitis, osteoblastoma, and fibrous dysplasia. Here, we present a case ofosteogenic sarcoma arising from florid osseous dysplasia appearing as a rapidly growing bony bulging mass in 44‐year‐oldKorean female who had at first been non‐symptomatic, but later suffered from the numbness of chin and lower lip. Theradiologic images revealed the mixed radiopaque‐ radiolucent intraosseous lesions throughout the mandible, which werediagnosed as florid osseous dysplasia pathologically. But only after 6 months, the lesions were substituted by the radiologicalill‐defined diffuse bony sclerotic lesion with bone destruction, accompanying the interrupted periosteal bone formation,which were pathologically diagnosed as osteogenic sarcomas. These serial clinicopathologic changes imply themalignant progression of florid osseous dysplasia rather than the collision of benign condition, florid osseous dysplasiaand malignant tumor, osteogenic sarcoma. The possibility for fibro‐osseous lesion of the jaw as premalignant lesionshould not be overlooked; therefore, periodic check‐ups for the lesions are necessary. Proper evaluation and interpretationfor clinical neural symptom and radiologic change of bone density may lead to the correct differential diagnosisand therapeutic intervention.