As human's average lifespan is gradually increased, the interest in the quality of life and health is also increasing. More and more customers like to use the facial manual technique as a way to live a healthy life, instead of using it as measures to simply improve skin troubles or to have beautiful skin. The facial manual technique performed in the skin care stage is closely related to the decrease of stress. In order to verify the effects of facial manual technique on the decrease of stress, an experiment was conducted in the same method by dividing 16 women residing in Seoul into four groups, from September 1st to September 30th 2016. To understand their general characteristics, perceptual stress, and satisfaction with facial manual technique through questionnaire, the frequency analysis and descriptive statistics were performed by using SPSS 22.0 program. The paired t-test was conducted to see changes in stress, LF, HF, LF/HF, average pulse, pulse standard, and average deviation before/after experiment. The stress index was decreased in every group. Especially, the group of the 20s showed a huge decrease(24.3%), which was significant to every group except for the 50s. In the results of LF, the group of the 20s and of the 30s increased 2.8% and 4.6% respectively, which was significant. In the group of the 40s, it was increased 4.0% while it was decreased 1.2% in the 50s. Rather than women in climacteric age, it was more effective for women in younger age. In results of pulse standard, it was increased 36.5% in the 20s, 63.6% in the 40s respectively, which was significant(p<0.05, p<0.01). In the group of the 30s and 50s, the significant values were not shown although it was still increased 48.3% and 65.1% respectively. In the survey of the facial manual technique, the whole participants showed positive responses to its effects on the decrease of stress. A majority of them took easy to control feelings, and it was highly possible for them to use it perio-dically in the future. It suggested that the effects of facial manual technique could play a role on recovering psychological stability and decrease of stress. It could be considered as a safe and effective healthcare method to improve the quality of human's life.

Central odontogenic fibroma(COF) is an extremely rare benign tumor that accounts for 0.1% of all odontogenic tumor. COF is regarded by the World Health Organization(WHO) as a benign odontogenic neoplasm derived from mesenchymal odontogenic tissue. The lesion occurs most commonly in the mandible and patients ranging in age from11 to 80years with mean age of 34years. In this article, we report two case of COF. Case I was associated odontoma and impacted tooth. Odontoma and impacted tooth was removal under general anesthesia. After microscopic examination, finally we diagnosis this lesion as COF. Patients of case II showed radiolucent lesion at the mandible. Lesion was enucleated under general anesthesia. After microscopic examination, finally we diagnosis this lesion as COF. The patients which we presented did not complain any specific complications, showed good prognosis.

Ameloblastoma is a benign odontogenic tumour of epithelial origin and comprises 1% of maxillomandibular tumors or cysts. The incidence of pathological changes such as ameloblastoma from the follicle of impacted third molar was reported to have low incidence. However, there are many reports that asymptomatic third molars are related with various pathological conditions. A case of ameloblastoma secondary to third molar extraction and subsequent sagittal split ramus osteotomy (SSRO) had not been reported. At the right ramus area, radiolucent lesion had been noted at 6 years after the surgical extraction of the third molar followed by SSRO for the mandibular prognathism. The lesion was proved to be the basal cell type ameloblastoma. There had been no significant bony lesion before or 1 year after the SSRO. The tumour was successfully removed and there was no evident recurrence at 4 year of the follow up after the removal of the ameloblastoma. There are some reports suggesting the pathologic potential of the pericoronal tissues of impacted third molars to develop odontogenic keratocysts and ameloblastomas. The current case reports a rare possibility of ameloblastic change at the site of uneventful healing after third molar extraction and orthognathic surgery.

Presence of a palato-nasally impacted supernumerary tooth with nasopalatine canal involvement is a unique finding that demands careful attention during surgical extraction due to its distinctive anatomy. In this case report of a 7-year-old child, an impacted supernumerary tooth had a developmental anomaly that required both palatal and nasal approaches to successfully remove the tooth.

Immortalization is an essential process of the transformation of cells to a neoplastic growth. High risk human papillomavirus (hrHPV) infection has been the major cause of head and neck squamous cell carcinoma (HNSCC). The aim of this study was to search for a novel pathway causing immortalization in HPV16 E6/E7 transfected immortalized oral keratinocytes (IHOK). hrHPV integration sites were identified through DNA sequencing. HPV16 E6/E7 genes were integrated into 1q32.2, 12q21.2, 15q15.2, and 19q13.43 in IHOKs. Array-CGH was conducted to examine the deranged sites of the genes of IHOK. Of the 587 amplification genes, 70 genes were resided on chromosome 20. We selected PLAGL2 and MAPRE1 as the most amplified genes. PLAGL2 and MAPRE1 mRNA showed higher expression in IHOK than in normal keratinocytes. Knockdown of MAPRE1 significantly reduced telomerase activity. The analysis using a public database substantiated our data, showing the amplification of chromosome 20 and MAPRE1. In conclusion, our results suggest that MAPRE1 could play a crucial role in activating telomerase activity in hrHPV-infected cells. This finding may provide basic data to develop a novel target therapy for hrHPV-related HNSCC.

Warthin’s tumor (Papillary cystadenoma lymphomatosum) is a benign salivary neoplasm initially. It is predominantly found in the parotid gland and accounts for about 10-15% of all benign tumors of the parotid gland. It is known that it had higher incidence in males and in smokers. Warthin’s tumor had moderate intensity on T1- and T2- weighted images on the magnetic resonance image (MRI). In this case, a 44-year-old man visited our dental hospital with induration and pain on the right preauricular region. The lesion showed high intensity on T2- weighted images on the MRI. We performed tumor removal, with the histopathologic examination confirming Warthin’s tumor. This report presents review of literature and describes a case of Warthin’s tumor with high T2- weighted magnetic resonance image and its surgical treatment.

"Cartilaginous choristoma" refers to as a tumorlike cartilaginous mass composed of normal tissues in an abnormal location. Oral cartilaginous choristomas are extremely rare. Although its rarity, most intraoral choristomas occur in the tongue. Adenomatoid hyperplasia of the minor salivary glands may be seen on the minor salivary gland bearing areas, especially seen on the palate. This report describes a case of firm mass on the left lateral tongue that was resulted cartilaginous choristoma associated with adenomatoid hyperplasia, which occurred in a 23-year-old male patient. And It hasn’t recurred during 17 months after complete excision.

Primary intraosseous odontogenic carcinoma (PIOC) is a carcinoma arising within the jaws, putatively developing from remnants of odontogenic epithelium. We describe a case of PIOC arising from odontogenic cyst affecting the left posterior mandible of 72-year-old Korean man. Clinical examination showed a symptom-free hard mass. There was no evidence of ulceration, and there was no pain or bleeding. The overlying mucosa was intact and no regional lymph nodes were palpable. Clinical and radiological studies for other distant primary sites were negative. Radiographically, the tumor showed multilocular radiolucency with a noncorticated, ill defined border surrounding an impacted third molar tooth. Histology exhibited sheets or islands of nonkeratinizing malignant epithelial cells with minimal clear cell component in continuity with begin or dysplastic cyst lining epithelium. Immunostaining for PCNA and p53 protein showed a higher percentage of positive cells and more intense staining in the carcinomatous tissues than in the benign and dysplastic lesions.

I have tried to make electronic listening and analyzing appratus, which were used for temporomandibular disorder patient’s. It can be heard T.M.J.D’s sounds. Normal person heard 20~20,000 Hz sound. Electronic appratus can capture furthermore. Electronic appratus composed of stethoscope rubber tube,small microphone, amplifier, telemetry, oscilloscope and speaker. The aim of oscilloscope and speaker are seen and heard T.M.J. sounds both dentists and patients.In developing countries, they use electronic stethoscope for diagnosis of heart sound and use for tele diagnosis. In my nation, laws of food and drugs were very rigid, so many researcher’s developed electronic stethoscope, but they could not produce it because of law. I suggest that soften the rigid law, and many new product will be produced. The apparatus that I developed was operated quite well both wired and wireless. It is suggested that we must develop new apparatus for T.M.D. patients and Telemedicine.