The role of CXCR7, a seven-transmembrane G-protein coupled chemokine receptor, which binds with high affinity to chemokine CXCL11 and CXCL12 in oral cancer cells and the effect of transient CXCR7-downregulation on proliferation and migration of oral squamous cell carcinoma (OSCC) cells have not been reported. The aim of the present study was to evaluate the effects of CXCR7 on an OSCC cell line. In this study, we down-regulated CXCR7 in the KOSCC25B OSCC cell line by siRNA. In vitro cell proliferation and migration assays were used to investigate the effect of CXCR7- downregulation on cell proliferation and migration in si.KOSCC25B cells. The CXCR7 down-regulated OSCC cells grew significantly slower than the negative control siRNA transfected KOSCC25B cells (p<0.05). Additionally, migration of si.KOSCC25B cells decreased significantly compared with non-transfected KOSCC25B cells (p<0.007). These results suggest that down-regulation of CXCR7 induces anti-proliferative and anti-migratory effects in OSCC, and that CXCR7 may be a useful target molecule for the treatment of OSCC.

White sponge nevus (WSN) is a rare autosomal dominant disorder characterised by rough thickening, fissure formation, and a whitish colour change in the oral mucosa. This disorder predominantly affects the nonkeratinized stratified squamous epithelium of the mucosa. We experienced a familial case of WSN (i.e., a mother and her two daughters) and performed keratin gene analysis and immunohistochemical staining. The results of a mutation analysis revealed the presence of a heterozygous missense mutation 344T to G in KRT13, predicting an amino acid change leucine (L) to arginine (R), in the 1A domain of the KRT13 polypeptide. Immunohistochemically, the loss of keratin 4 expression was found.

The dentigerous cyst is defined as a cyst that originates by the separation of the follicle from around the crown of an unerupted tooth. This is the most common type of developmental odontogenic cyst, making up about 20% of all epithelium-lined cysts of the jaws. Large dentigerous cysts are uncommon, but some cases are large cysts. The usual treatment for a dentigerous cyst is careful enucleation of the cyst together with removal of the unerupted tooth. Large dentigerous cysts also may be treated by decompression. This permits decompression of the cyst, with a resulting reduction in the size of the bone defect. The cyst can then be enucleated at a later date with a less extensive surgical procedure and important structures such as teeth and the inferior alveolar nerve can be preserved. These cases are large dentigerous cysts treated by decompression. Less extensive surgical procedures were used and some teeth were preserved.

Acinic cell carcinoma is a well-differentiated, low-grade tumor that accounts for 1-3% of salivary gland tumors. Among the variant of acinic cell carcinoma, papillary cystic variant of acinic cell carcinoma is much more rare and it is known to be difficult to diagnose and has a poor prognosis. In this paper, we report a case of 58 - year - old man diagnosed as papillary cystic variant of acinic cell carcinoma and the characteristics of the lesion by integrating the recent cases of papillary cystic variant of acinic cell carcinoma. This study emphasizes the need for long-term studies and further investigation of papillary cystic variants of acinic cell carcinoma.

Kaposi’s sarcoma is one of the first recognized in HIV infection even patient can develop KS in any disease stage. Moreover, the oral cavity may be the first site of Kaposi’s sarcoma and oral mucosa involvements of KS in HIV positive are very critical because it had a higher death rate than those who having exclusively cutaneous manifestations of the disease. Early detection of KS oral involvement is very important to prevent disease burden. This case is about a 48 years old male who was first discovered Oral Kaposi’s Sarcoma as HIV infection sign. He didn’t notice any other discomfort other than oral mucosa swelling.

Tooth autotransplantation is the placement of an impacted or erupted tooth into an extraction site or surgically prepared dental socket within the same individual. This procedure may become a new treatment alternative, because of its osteogenetic potential and its ability to promote regeneration of alveolar processes. The present study reports the case of a 10-year-old girl whose maxillary central incisor was ankylosed as the result of an injury, and who underwent tooth autotransplantation and orthodontic treatment for the functional and aesthetic recovery of the maxillary central incisor. The transplanted tooth showed satisfactory alveolar bone recovery, and orthodontic tooth movement. No complications occurred. We chose to report this case because it illustrates the autotransplantation of a premolar in a child scheduled for orthodontic treatment, including tooth extraction. The procedure showed good prognosis in terms of the recovery of an anterior tooth affected by an injury

5-fluorouracil (5-FU) is a pyrimidine analog which can work as antineoplastic antimetabolite by blocking thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid in DNA synthesis. This study is aimed to know the anticancer effect of 5-FU on the expressions of important signaling proteins in KB cells through immunoprecipitation high performance liquid chromatography (IP-HPLC). KB cells were treated with 5 µM 5-FU and cultured for 12, 24, 48, 72, and 96 hours, and followed by IP-HPLC analysis using 32 antisera. 5-FU suppressed the proliferation of KB cells by decreases in the expressions of proliferation-related proteins, Ki-67, PCNA, CDK4, and MPM2 to 82.6%, 92.4%, 95.2%, and 95.9%, respectively, but increases of antiproliferation-related proteins, p16 and p21 to 106.7% and 125.5%, respectively, during 96 hours of experiment. This proliferation reduction was also negatively regulated by cMyc/MAX/MAD network signaling. The cellular protection and survival were consistently arrested by 5-FU treatment in KB cells. The expressions of NFkB, MDR, p-mTOR, and TNFα were decreased to 95.1%, 92.8%, 93.4%, and 90.3% in 48-72 hours, respectively, while cellular stress was increased by upregulation of p38 to 111.3% in 48 hours. And the expressions of pAKT1/2/3, hTERT, and AMPK were also decreased to 93.3%, 97.4%, and 89.3% in 24-48 hours, respectively, while the cellular transformation might be undergone by upregulation of TGF-β1 to 117% until 96 hours. Particularly, 5-FU treatment greatly induced the cellular apoptosis in KB cells by increased expressions of PARP, cPARP, caspase 9, c-caspase 9, caspase 8, and caspase 3 in the lack of p53/BAX and FASL/FAS signaling. The expressions of PARP and c-PARP were increased maximum to 119.2% in 24 hours, and followed by increases of caspase 9, c-caspase 9, caspase 8, and caspase 3 to 111.2%, 125.9%, 108.6%, and 116.3% in 72-96 hours. Therefore, it is presumed that 5-FU induced cellular apoptosis in KB cells may be derived from the overexpression of PARP due to the increased DNA defect caused by 5-FU, which can lead to ATP depletion and subsequent cellular apoptosis.

Canalicular adenoma is an uncommon, benign salivary gland tumor. It has a significant predilection for occurrence in the minor salivary glands, with most cases occurring in the upper lip, followed by the buccal mucosa and palate. Rarely, canalicular adenoma can involve the major salivary glands, such as the parotid gland. Only a small number of cases of canalicular adenoma of the parotid gland have been reported in the literature. We report a rare case of canalicular adenoma on the left parotid gland of an 81-year-old man, and present a review of the literature.

There are many case reports about cysts within the bones of the jaws associated with impacted third molars. When osmotic pressure is introduced into a cyst, the cyst expands and displaces the third molar. If continuity of cyst wall is lost, cystic expansion cannot occur, and the cyst cannot displace the third molar. This study analyzed four cases of pathologic migration of the third molar in ruptured cystic lesions that had formed bone tunnels and intraoral fistulas to identify the causes and factors contributing to this migration. Authors hypothesized that closure of fistulas repeated generation of pressure, it may temporarily increase the osmotic pressure within a cyst that has lost its continuity, causing displacement of the third molar. A cyst that has lost its continuity due to fistula formation within the oral cavity can cause ectopic displacement of the adjacent impacted teeth.

The most common benign salivary gland tumor is pleomorphic adenoma. It affects major and minor salivary glands. Minor salivary gland tumors constitute <20% of all salivary gland neoplasms. Most minor salivary gland tumors occur on the palate. We present the case of a patient with pleomorphic adenoma that developed at a rare intraoral location. This patient presented to the Department of Oral and Maxillofacial Surgery of Seoul National University Dental Hospital.

The odontoma is a hamartomatous lesion consisting of enamel, dentin, pul and cementum. They are observed in the form of a tooth or as a mass of agglomerated teeth. Most of these occur during the period of development of normal teeth and grow to some extent. The fused tooth was the developmental abnormality of the teeth and the hard tissues of the adjacent teeth were combined. In general, these two lesions are not related, but two problems can occur together with systemic or local causes in the morphological differentiation period. We report a case of a 6 - year - old boy who visited our clinic for the eruption of a calcified mass in the mouth. The patient was diagnosed by the fusion of a odontoma and a mandibular permanent anterior tooth. And then, fused odontoma was removed surgically and the mandibular permanent anterior was restored by using composite resin. Calcified material was diagnosed as a composite tooth. After 6 months, the permannant teeth was satisfactory eruption and did not show any pathological problems in periapical radiography.

Pleomorphic adenoma is the most common benign tumor of the salivary glands. About 80-90% of pleomorphic adenoma occurs in the parotid gland and about 5-10% of them occur in the submandibular gland and sublingual gland. The rest proportion comprises the minor salivary glands. The palate is the most common area, followed by the lips and the cheeks. Pleomorphic adenoma of the submandibular gland shows clinically a slow-growing, painless mass found on submandibular aspect. In this case report, we report a case of pleomorphic adenoma of the right submandibular gland in a 63-year old female patient who was referred from the department of neurosurgery, due to the heterogenous mass detected by computed tomography (CT) and magnetic resonance imaging (MRI)