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Pleomorphic adenoma is the most common benign tumor of the salivary glands. About 80-90% of pleomorphic adenoma occurs in the parotid gland and about 5-10% of them occur in the submandibular gland and sublingual gland. The rest proportion comprises the minor salivary glands. The palate is the most common area, followed by the lips and the cheeks. Pleomorphic adenoma of the submandibular gland shows clinically a slow-growing, painless mass found on submandibular aspect. In this case report, we report a case of pleomorphic adenoma of the right submandibular gland in a 63-year old female patient who was referred from the department of neurosurgery, due to the heterogenous mass detected by computed tomography (CT) and magnetic resonance imaging (MRI)