치자 열매로부터 추출한 topoisomerase I 효소 저해제의 구조 동정과 활성에 관한 연구
페이지 정보
본문
Topoisomerases are essential enzymes involved in all processes of DNA metabolism, and their inhibitors have been identified as
potential anti-cancer agents. The present study examined the effect of linoelaidic acid (C18 polyunsaturated fatty) compounds derived
from Gardenia jasminoids Ellis extract on the activity of eukaryotic topoisomerases inhibition. The present study identified linoelaidic
acid compounds using open column fraction, HPLC, NMR and LC/MS which have effects on cell death in oral cancer cell line,
FaDu, but not in immortalized normal cell line, HaCaT. Subsequent studies revealed linoelaidic acid-induced autophagy through LC3
activation. Finally, its inhibition of topoisomerase I and selectively induction of oral cancer cell death possibly implies that linoelaidic
acid can be a role as potenial agents in the prevention and therapy of oral cancer.
potential anti-cancer agents. The present study examined the effect of linoelaidic acid (C18 polyunsaturated fatty) compounds derived
from Gardenia jasminoids Ellis extract on the activity of eukaryotic topoisomerases inhibition. The present study identified linoelaidic
acid compounds using open column fraction, HPLC, NMR and LC/MS which have effects on cell death in oral cancer cell line,
FaDu, but not in immortalized normal cell line, HaCaT. Subsequent studies revealed linoelaidic acid-induced autophagy through LC3
activation. Finally, its inhibition of topoisomerase I and selectively induction of oral cancer cell death possibly implies that linoelaidic
acid can be a role as potenial agents in the prevention and therapy of oral cancer.
첨부파일
-
2014032815D019.pdf (0byte)
28회 다운로드 | DATE : 2020-02-25 00:00:00
- 이전글635-nm 발광 다이오드가 임플란트 주위염 in vitro 모형에 미치는 효과 20.02.25
- 다음글함치성낭에서 치성 섬유종성 증식 20.02.25
댓글목록
등록된 댓글이 없습니다.