제목 diagrammatic representation of the normal hemostatic process
작성자 김옥준                                                                           작성일    2003-02-06 14:52:45
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내용
A, After vascular injury, local neurohumoral factors induce a transient vasoconstriction. B, Platelets adhere to exposed extracellular matrix (ECM) via von Willebrand factor (vWF), and are activalted, undergoing a shape change and granule release; released adinosine diphosphate (ADP) and thromboxane A₂(TXA₂) lead to further platelet aggregation to form the primary hemostatic plug. C, Local activation of the coagulation cascade (involing tiffue factor and platelet phospholipids) results in fibrin polymerization, "cementing" the platelers into a definitive secondary hemostatic plug. D, Counter-regulatory mechanisms, such as release of tissue type plasminogen activator (t-PA) (fibrinolytic) and thrombomodulin (interfering with the coagulation cascade), limit the hemostatic process to the site of injury.
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