제목 A role of p-AKT on epithelial-mesenchymal transiti
작성자 Kyoung-Ok Hong, Ji-H                                                                           작성일    2006-04-26 23:59:12
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A role of p-AKT on epithelial-mesenchymal transition(EMT) in oral cancer

 

Kyoung-Ok Hong, Ji-Hong Kim, Ji-Soo Hong, Jae-Il Lee, Sam-Pyo Hong,

Seong-Doo Hong

Dept. of Oral Pathology, College of Dentistry, Seoul National University, 28-2 Yeongeun-dong, Jongno-gu, Seoul, 110-744, Korea.

 

     Epithelial-mesenchymal transition (EMT) is an important process during development          and oncogenesis by which epithelial cells acquire fibroblast-like properties and show             reduced intercellular adhesion and increased motility. Also, the process of EMT plays a        pivotal role in the conversion of early stage tumors into invasive malignancies, and has          been shown to be regulated by the transcriptional factor, Snail. Recently, activation of          the phosphatidylinositol 3' kinase (PI3K)/AKT axis is emerging as a central feature of          EMT. However, it is unclear whether the phosphorylation of AKT regulate the                    expression of snail in oral cancer cell underwent EMT. To investigate a role of p-AKT in       EMT, we assessed the effects of inhibiting p-AKT activity in oral squamous cancer cells

    (KOSCC-25B) using PIAs, structurally modified phosphatidylinositol ether lipid analogues      (PIAs). PIAs decreased phosphorylation of a number of downstream targets of AKT, such      as extracellular signal regulated kinase (ERK), glycogen synthase kinase 3beta

    (GSK-3beta) and NF-kB. These findings suggest that future therapies based on p-AKT         inhibition may provide more effective strategy to control tumor cell invasion and                   metastasis.

 



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