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년도별 일람

Total 768건 17 페이지
576 2015

잇솔질 패턴 분석을 위한 모니터링 시스템 개발

저자 김옥수, 김상우, 김지선, 최홍란, 김옥준

초록

Proper oral hygiene is required to maintain oral health and prevent oral disease. Toothbrushing is central to proper oral hygiene. Mechanical tooth cleaning is the mainstay of plaque control. A variety of toothbrushing techniques have been developed and evaluated for their efficacy. However, these evaluations are subjective. To adequately evaluate toothbrushing objectively, a novel toothbrushing monitoring system was developed. The system involves user-monitored brushing patterns including toothbrush motions using a 3-axis gyroscope, 3-axis accelerometer, 3-axis magnetic sensor, one load-cell and Bluetooth devices. To confirm the efficacy of this toothbrushing monitoring system, eight periodontist performed tooth brushing in a dental model, and their brushing motion was monitored and recorded, and evaluated by statistical means. The proposed monitoring system can be used to aid dental care personnel in toothbrushing instruction.

575 2015

세포부착 PHBV-교원질 나노섬유의 골유도재생 효용성 평가

저자 신홍인

초록

This study was performed to improve the efficiency of guided bone regeneration by adapting the tissue-engineered bone regeneration approach. The PHBV-collagen nonofibrous membranes cultured with rat calvarial periosteum derived cells in osteogenic culture medium for 7 days were applied to 5 x 2mm size artificial rat tibial defects for 3weeks and evaluated its efficiency as an alternative cell engineered membrane for effective guided bone regeneration by routine histological observation. The defects covered with cell attached PHBV collagen nanofibrous membrane complexes showed favorable bone repair compared to both membrane non-covered control and membrane only covered group without specific side effects. These findings suggest that the favorable guided bone generation can be achieved by adapting the tissue engineered bone regeneration approach using PHBV-Collagen nanofibrous membrane scaffold.

574 2015

한국인 구강편평세포암종 환자의 다단계 발암과정에서 Visfatin의 발현 분석

저자 박세라, 한혜연, 김지연, 배문경, 유미현, 배수경

초록

Visfatin is a pro-inflammatory cytokine, which is thought to play a central role in systemic inflammation and the pathogenesis of obesity related diseases. Only a few studies investigated the effect of visfatin on human cancers. Furthermore, there have been no studies on the association between the expression of visfatin in OSCC tissue and its effect on OSCC patients. Hence, the present study analyzed the expression of visfatin in OSCC from Korean patients. Immunohistochemistry for visfatin was performed using 12 normal oral mucosas (NOM), 16 oral leukoplakias (with/without dysplasia), and 58 OSCC patients samples. Immunoreactivity was semi-quantitatively scored and the correlation between the expression of visfatin and clinicopathological parameters of OSCC patients was analyzed. The immunohistochemical analysis demonstrated that the expression level of visfatin increased in OSCC alone (p‹0.05). Moreover, the immunoexpression score of visfatin was significantly correlated with TNM stage of OSCC patients. Our findings suggested that visfatin can play a certain role in the pathogenesis of OSCC. In addition, visfatin was associated with the tumor progression of OSCC patients and may act as independent biomarker of OSCC.

573 2015

사람 구강암세포에서 Terfenadine의 시험관내 아팝토시스 효과

저자 원동훈, 유현주, 조남표, 조성대

초록

Terfenadine (TFN) was a second generation histamine receptor antagonist. Although several studies have reported the regulatory effect of H1-histamine receptor antagonists in human cancer cell lines, its effect in oral cancer remains unclear. In this study, we focused on addressing the anti-cancer activity of TFN in human oral cancer cell lines. The anti-cancer activities of TFN were performed by tryphan blue exclusion assay, 4’-6-diamidino-2-phenylindole (DAPI) staining, live/dead assay and Western blot analysis. TFN induced a significant reduction of the growth in three different human oral cancer cell lines (MC3, HSC4 and Ca9.22). TFN markedly induced apoptosis through DNA damage and increase in cytotoxicity. It also accumulated cleaved PARP and caspase 3. This process was due to cleavage of caspase 8 and Bid protein. The results from this study strongly demonstrated that the cleavages of caspase 8 and Bid are required for the apoptotic activity of TFN in human oral cancer cells. Taken together, these findings suggest TFN as a potent anticancer drug candidate for the treatment of oral cancer

572 2015

치주염 환자의 구강에서 분리된 독성요인에 관한 Staphylococcus aureus의 분자감시

저자 김가연, 김진경, 이영기

초록

S. aureus is reported as a major cause of nosocomial infections after dental care and involved in endocarditis, bacteremia, osteomyelitis, peritonitis, and soft tissues etc. It is very important to identify the distribution and the diversity of toxin gene associated with the S. aureus expression in dental care patients with periodontitis directly for an effective prevention and treatment of dental diseases. Fifty four strains of S. aureus were isolated from the saliva of 129 patients who were diagnosed with periodontitis at dental clinics and hospitals located in Seoul. The distribution of the virulence gene and the genetic diversity of the strains were studied using the polymerase chain reaction with isolated strains. The enterotoxin test showed Seb was the most frequent gene with 88.9%. The hemolysin gene of Hla, Hib and Hld were the most frequently gene with 98.1% (53 strains), leukocidins gene of lukM showed 90.7% (49 strains), and laminin binding protein gene of Eno showed 100% (54 strains), respectively. The diversity of the enterotoxin gen was held as Seb-Seg-Sei gene of 35.2% (19 strains), the diversity of hemolysin gene of Hla-Hlb-Hld gene was 98.1% (53 strains) and the diversity of leukocidins gene of LukD-LukM were 88.9% (48 strains), respectively. Patients with dental disease showed somehow high toxin gene expression so that S. aureus in dental care area is judged to show very highly pathogen with a high and infection rate. In the future, additional studies for these toxin genes seem to be required.

571 2015

세포의 증식 및 냉동 보관을 위한 PHBV 나노 섬유막의 효용성 평가

저자 신홍인

초록

The PHBV nonofibrous membrane fabricated by electron-spinning method for tissue engineered bone regeneration scaffold was evaulated in terms of cellular prolieration and cryopreservation efficiency. The rat calvarial periosteum derived primary cells were cultured with PHBV nanofibrous membranes and analyzed the cellular proliferation and differention fashion and cryopreservation potential by in vitro MTT assay as well as ALP staining and Alizarine red staining with or without cryopreservation for 2 weeks. The rat calvarial periosteum derived primary cells cultured with PHBV nonofibrous membrane showed favorable proliferation and alkaline phosphatase activity with numerous mineral nodule formation regardless of cryopreservation, even though its efficiency was slightly decreased in cryopreserved condition. These findings suggest that PHBV nanofibrous membrane can be applicable as an efficient cell engineered membrane for guided bone regeneration or scaffold for tissue engineered bone regeneration.

570 2015

한국 성인의 전신건강상태와 치주질환과의 관련성 분석- 2012년도 제 5기 국민건강영양조사 결과 분석 -

저자 이선미, 김기열, 김진

초록

" The purpose of this study was to synthetically examine the relationship between systemic diseases and periodontal diseases. The data obtained from the Fifth Korea National Health and Nutrition Examination Survey were used. SPSS 18.0 for Windows was applied for statistical analysis. The surveyed data were analyzed by using independent sample t-test for the difference between Body Mass Index and clinical test according to the existence of periodontal disease, and X2 test for the relationship between periodontal disease and systemic disease. Multiple logistic regression analysis was used in order to figure out the influence upon the periodontal disease prevalence among general characteristics and systemic diseases. As results, the values of high density lipoprotein (HDL) and HBA1C were statistically significant, depending on the presence of periodontal disease. As for the relationship between periodontal disease and systemic disease, hypertension (odds ratio 1.362, p<0.05), cardiovascular disease (odds ratio 2.118, p<0.05), arthritis (odds ratio 1.289, p<0.05) and cirrhosis (odds ratio 6.124, p<0.05) were statistically significant. According to Multiple logistic regression analysis, gender (odds ratio 1.24, p<0.05), alcohol intake (odds ratio 1.25, p<0.05), cardiovascular diseases (odds ratio 1.56, p<0.05), and liver cirrhosis (odds ratio 1.17, p<0.05) were related to the prevalence of periodontal diseases. In conclusion, the systemic diseases such as cardiovascular system, diabetes, and liver diseases revealed to have relationship with periodontal disease. To strengthen oral health education is needed to enhance systemic health as well as oral health. Moreover, basic biological research should be followed to support this surveyed study."

569 2015

목 부위에서 발생한 세포성 혈관섬유종-증례보고 및 문헌 고찰-

저자 김하나, 쿠니, 김지선, 김상우, 전상미, 최홍란, 김옥준

초록

" We present a case of cellular angiofibroma arising from right neck in a 46-year-old woman. Surgical excision was performed and the patient was disease free till now. Cellular angiofibroma usually arised in the inguinoscrotal of vulvovaginal regions. Only 3 cases of cellular angiofibroma involving maxillofacial region have been reported in the english written literature. Cellular angiofibromas are rare benign tumor characterized by bland spindle shaped cells arranged in a stroma with wispy collagen and numerous vessels. Immunohistochemical stains of the tumor cells showed the positivity for CD34, PR, EMA, but negativity for neurofilament, desmin and actin. The tumor should be differentiated from aggressive angiomyxoma and angiomyofibroblastoma, angiofibroma because of its clinical and histological similarity. We report a rare case of benign cellular angiofibroma involving right neck and study other published articles."

568 2015

하악 후구치부에 발생한 주변성 법랑모세포종

저자 유태훈, 최승현, 나종찬, 안미영, 이준, 윤정훈

초록

Peripheral ameloblastoma, a rare and unusual variant of odontogenic tumor, representing 1% of all ameloblastomas. The extraosseous location is the peculiar feature of this type of tumor, which is otherwise similar to the classical ameloblastoma. This paper describes a case of peripheral ameloblastoma in a 43-year-old female affecting the left retromolar pad area of the mandible which was clinically diagnosed as a pyogenic granuloma. Histologically, the tumor showed of follicular ameloblastoma in continuity with a surface oral epithelium.

567 2015

치과용 임플란트 삽입을 위한 이종 이식골에서 보이는 치성상피의 이형성증식

저자 이상신, 김연숙, 이석근

초록

A 57 years old female received xenogenic bone graft for the extraction socket augmentation of right maxillary molars and for the sinus floor elevation six months ago. The bone graft sites were healed uneventfully and showed marked radiopacity in the postoperative X-ray view. Before dental implant insertion the bone biopsy was made using trephine bur and examined pathologically. The graft bones showed minimum new bone deposition with dysplastic epithelium. The epithelium was proliferative on the surface of graft bones forming epithelial strands and nests, similar to the odontogenic epithelium. The immunohistochemical study was performed using different antisera of odontogenic markers, growth factors, oncogenes, etc. The epithelial cells were strongly positive for pan-keratins, EGF, pAKT, and HSP-70, consistently positive for PCNA, p53, EGFR, 14-3-3, and survivin, slightly positive for ameloblastin, but rarely positive for amelogenin. Particularly the matrix of graft bone was slightly positive for EGF. Taken together, it is presumed that the abnormal epithelium on the graft bones was derived from odontogenic epithelial elements, Malassez epithelial rests, distributed at the periodontal tissue of maxillary molars, and that they might undergo dysplastic proliferation affected by the release of growth factors and osteogenic proteins from the graft bones. It is also suggested that the graft bone substitutes inserted for the dental implant possibly have a potential to induce the proliferation of odontogenic epithelial rests leading to the pathogenesis of odontogenic cysts and tumors.

566 2015

곡예운동이 멀미 지표 및 전정안구반사에 미치는 효과

저자 이석준, 박우영

초록

The theory of visuo-vestibular conflict is the most commonly accepted to explain motion sickness. Visual, vestibular and proprioceptive afferences are in involved in balance control and this function can be improved by physical and sport activity. The purpose of the present survey was to investigate the relationships between motion sickness susceptibility in elite gymnastic & figure skating player physical activity and especially acrobatic exercise. We quantified vestibular-ocular reflex(VOR) in intensity in 7 figure skating and 7 age matched control subjects. Sensory organization test were by posturography in neuroCom EquiTest and vestibular stimulation consisted of four cycles of sinusodial rotation(.01, 04, .16, .64Hz, 60°/s) and was tested by system 2000 micromedical, Chatham, IL. The results of the study were as follow: The results are as follow. Balance score in condition 5, 6 were significantly higher than control. During sinusodial stimulations, the skaters’VOR, as compared with that of the controls, demonstrated a gain that significantly lower(p<.01), than in control one. Quantitative alterations in VOR parameters observed in gymnastic and figure skaters probably result from vestibular habituation induced by repeated unusual stimulations when practicing.

565 2015

Adenocarcinoma&#44; NOS의 세포 형태학적&#44; 구조적인 특징에 관한 연구

저자 김보경, 강경림, 이재일

초록

As the designated name, adenocarcinoma, not otherwise specific (ANOS) revealed lack of histomorphologic characteristics that could classify the tumors under specific name. ANOS had nothing in common with other salivary gland malignancies, but glandular differentiation. The purpose of this study is to find out the solid characteristics of ANOS on the base of cytological and architectural features. 20 ANOS cases were studied. We identified 20 patients with salivary adenocarcinoma, not otherwise specified, ranging in age from 26 to 76 years (median, 53.85 years), with slight female predilection (female 11: male 9). The minor salivary gland was the most common site of tumor origin, especially on the palatal area (11 out of 20). The size of tumor was from 1.0 to 7.0(median 3.07). For the histopathological analysis, we classified the tumors by cytological and architecture patterns. Basaloid and epitheloid cytological patterns were showed with solid, microcystic/pseudocystic architecture. We found invasive growth patterns in 7 out of 20 cases. Reviewing and classifying the common features of ANOS could be helpful to make a diagnosis of malignant salivary gland tumors.

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